In this study, we have analyzed 323 SARS-CoV-2 complete genomes sequenced in Bangladesh till October 1st, 2020. Phylogenetic analysis revealed that among the SARS-CoV-2 viruses detected in Bangladesh, the ones belonging to GH and GR clades originated in the UK, the ones in G and O clades in Italy and the ones in S and O clades originated in China. From our analyses, it was discovered that the majority of the SARS-CoV-2 found in Bangladesh belonged to the lineage B 1.1.25 of GR clade.
Our study proposed, designed and tested three novel inhibitors, UN-1, UN-2 and UN-3 against SGp and Mpro of SARS-CoV-2 and its variants. Binding of these inhibitors to the target proteins may eventually create hindrance in entering host cells and in viral replication. Full work published in [RSC Advances](https://pubs.rsc.org/en/Content/ArticleLanding/2021/RA/D1RA04107J#fn1)
This study focused on some novel mutations in the NSP1 and NSP3 proteins of SARS-CoV-2. NSP1 is a potent virulence factor of Betacoronavirus and hence a potential target for an attenuated vaccine. PLPro of SARS-like coronavirus has appeared as suitable targets for the development of anti-SARS therapeutics. In the future, wet lab research on the mutants will accelerate research and developments regarding attenuated vaccines and antiviral drugs. Full work published in [Journal of Genetic Engineering and Biotechnology](https://jgeb.springeropen.com/).
This study has proposed four types of therapeutics including chimeric vaccine, potent drugs, siRNAs and ISG targets against COVID–19. We have analyzed all the genomic, host transcriptomic and proteomic data to anticipate the possible therapeutics against the recent pandemic COVID–19. Therefore, these findings might be of interest to the researchers and pharmaceuticals company to discover the novel therapeutics against the SARS-CoV–2. Full work published in [Gene](https://www.sciencedirect.com/journal/gene).
This thesis is part of the BCSIR-NIB mNGS collaboration project, which focuses on the application of shotgun metagenomics for the characterization of the Oropharyngeal sample collected from Covid-19 patient. Click **Video** Button for a Quick Walkthrough.
We have performed whole genome sequencing of SARS-CoV-2 to identify genetic variations and then analyzed their impact on the structures of their corresponding proteins. We have also identified the insertions/deletions among all the sequenced Bangladeshi SARS-CoV-2 strains. The energy minimization and the drug binding analysis suggested that the identified mutations might have significant impact on structure and function of their target proteins. Full work published in [RSC Advances](https://pubs.rsc.org/en/content/articlelanding/2021/RA/D1RA05327B).