Whole Genome Sequencing for Revealing the Point Mutations of SARS-CoV-2 Genome in Bangladeshi Isolates and their Structural Effects on Viral Proteins
We have performed whole genome sequencing of SARS-CoV-2 to identify genetic variations and then analyzed their impact on the structures of their corresponding proteins. We have also identified the insertions/deletions among all the sequenced Bangladeshi SARS-CoV-2 strains. The energy minimization and the drug binding analysis suggested that the identified mutations might have significant impact on structure and function of their target proteins. Full work published in RSC Advances.
TAILORED BIOINFORMATICS & MACHINE LEARNING APPROACH FOR HACKING INTO COVID-19 MICROBIAL SYSTEM
This thesis is part of the BCSIR-NIB mNGS collaboration project, which focuses on the application of shotgun metagenomics for the characterization of the Oropharyngeal sample collected from Covid-19 patient. Click Video Button for a Quick Walkthrough.
Recognition of Plausible Therapeutic Agents to Combat COVID-19: An Omics Data Based Combined Approach
This study has proposed four types of therapeutics including chimeric vaccine, potent drugs, siRNAs and ISG targets against COVID–19. We have analyzed all the genomic, host transcriptomic and proteomic data to anticipate the possible therapeutics against the recent pandemic COVID–19. Therefore, these findings might be of interest to the researchers and pharmaceuticals company to discover the novel therapeutics against the SARS-CoV–2. Full work published in Gene.
Protein-Protein Interactions Network Model underlines the Link between Hormonal and Neurological Disorders
We have nally predicted possible relationships between the protein IGF1 and its interacting partners SOX2, SOX4 and SOX9 in diseases such as type 1 diabetes, sensorineural hearing loss and intellectual disabilities which should be investigated further for unveiling the molecular mechanisms and discovery of novel biomarkers.
Pathogenic Genetic Variants From Highly Connected Cancer Susceptibility Genes Confer the Loss of Structural Stability
BRCA1, ATM and TP53 protein plays a significant role as tumor suppressor in several cancer types. The present study showed that some plausible genetic variants could destabilize the protein structure and ultimately might play a critical role in altering the biological function of the respective gene. Full work published in Scientific Reports
Novel Mutations in NSP1 and PLPro of SARS-CoV-2 NIB-1 Genome Mount for Effective Therapeutics
This study focused on some novel mutations in the NSP1 and NSP3 proteins of SARS-CoV-2. NSP1 is a potent virulence factor of Betacoronavirus and hence a potential target for an attenuated vaccine. PLPro of SARS-like coronavirus has appeared as suitable targets for the development of anti-SARS therapeutics. In the future, wet lab research on the mutants will accelerate research and developments regarding attenuated vaccines and antiviral drugs. Full work published in Journal of Genetic Engineering and Biotechnology.
Newly designed analogues from SARS-CoV inhibitors mimicking the druggable properties against SARS-CoV-2 and its novel variants
Our study proposed, designed and tested three novel inhibitors, UN-1, UN-2 and UN-3 against SGp and Mpro of SARS-CoV-2 and its variants. Binding of these inhibitors to the target proteins may eventually create hindrance in entering host cells and in viral replication. Full work published in RSC Advances
Molecular characterization and functional annotation of a hypothetical protein (SCO0618) of Streptomyces coelicolor A3(2)
This study was aimed to determine the structural and biological function of SCO0618, a hypothetical protein of this bacterium through an in-silico approach. Full work published in Genomics & Informatics.
Comparative Genomic Study for Revealing the Complete Scenario of COVID-19 Pandemic in Bangladesh
In this study, we have analyzed 323 SARS-CoV-2 complete genomes sequenced in Bangladesh till October 1st, 2020. Phylogenetic analysis revealed that among the SARS-CoV-2 viruses detected in Bangladesh, the ones belonging to GH and GR clades originated in the UK, the ones in G and O clades in Italy and the ones in S and O clades originated in China. From our analyses, it was discovered that the majority of the SARS-CoV-2 found in Bangladesh belonged to the lineage B 1.1.25 of GR clade.
